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KMID : 0620920170490080010
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Experimental & Molecular Medicine
2017 Volume.49 No. 8 p.10 ~ p.10
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Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling
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Kim Ji-Cheol
Jung Young-Su
Lee Ha-Young
Park Joon-Seong
Bae Yoe-Sik
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Abstract
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In this study, we report that an acute phase reactant, serum amyloid A (SAA), strongly inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased the expression of MHCII and CD11c. Moreover, SAA decreased cell surface GM-CSF receptor expression. SAA also decreased the expression of PU.1 and C/EBPα, which play roles in the expression of GM-CSF receptor. This inhibitory response by SAA is partly mediated by the well-known SAA receptors, Toll-like receptor 2 and formyl peptide receptor 2. Taken together, we suggest a novel insight into the inhibitory role of SAA in dendritic cell differentiation.
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KEYWORD
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Hormone receptors, Myelopoiesis
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